High-throughput Genome-editing Screening to Discover Novel Targeted Therapies
Based on high-throughput gene editing technology, we identify the novel functional biomarkers or novel combination of targeted therapy via synthetic lethal screen and develop the innovative targeted therapies for solid tumor.
High-throughput Genome Editing Screening Technology
Our Research:Genome Editing
Introduction of High-throughput Genome Editing Screening Platform
R&D of Effective Drugs
The identification of drug targets plays important roles in the success of mechanism-based drug discovery and is crucial to link drug response to genetic variation. Based on gene editing approach, the iBAR technology allows us to conduct the high-throughput loss-of-function screens at high MOI with lower false discovery rates and higher signal-to-noise ratios. These improvements make the iBAR technology as a powerful tool in genetic research for drug targets discovery and come up with better clinical gene therapy.
Precise identification of functional elements for a potential lead compound/drug target is pretty important for achieving a lead compound/drug mechanistic understanding and the personalized precision medicine. CRISPR-empowered Tiling Mutagenesis combined with Assorted-DNA-fragment Sequencing provides a streamlined workflow and bioinformatics analytics for identifying critical elements of proteins in their native biological contexts at the single amino acid level.
The technology can help to:
- Research and explore the truly functional amino acids for a potential lead compound/drug target
- Research and explore the specifically functional region for a potential lead compound/drug target
We Develop Innovative Targeted Therapies for Solid Tumor