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Utilizing AAV-mediated LEAPER 2.0 for programmable RNA editing in non-human primates and nonsense mutation correction in humanized Hurler syndrome mice
Zongyi Yi, Yanxia Zhao, Zexuan Yi, Yongjian Zhang, Gangbin Tang, Xiaoxue Zhang, Huixian Tang, Wei Zhang, Ying Zhao, Huayuan Xu, Yuyang Nie, Xueqing Sun, Lijun Xing, Lian Dai, Pengfei Yuan & Wensheng Wei. Utilizing AAV-mediated LEAPER 2.0 for programmable RNA editing in non-human primates and nonsense mutation correction in humanized Hurler syndrome mice. Genome Biology. https://genomebiology.biomedcentral.com/articles/10.1186/s13059-023-03086-6
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Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo
Yi, Z., Qu, L., Tang, H. et al. Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo. Nature Biotechnology. https://doi.org/10.1038/s41587-021-01180-3.
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Highly efficient gene editing and single cell analysis of hematopoieticstem/progenitor cells from X-linked sideroblastic anemia patients
Fang R, Zhang J, Yang H, Shi J, Zeng H, Zhu X, Wei D, Yuan P, Cheng T, ZhangY. Highly efficient gene editing and single cell analysis of hematopoieticstem/progenitor cells from X-linked sideroblastic anemia patients. Signal Transduct Target Ther. 2021 Jul 2;6(1):248. doi: 10.1038/s41392-021-00622-3.PMID: 34210953; PMCID: PMC8249499.
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PASTMUS: Mapping functional elements at single amino acid resolution in humancells
Zhang X, Yue D, Wang Y, Zhou Y, Liu Y, Qiu Y, Tian F, Yu Y, Zhou Z, Wei W.PASTMUS: mapping functional elements at single amino acid resolution in humancells. Genome Biol. 2019 Dec 16;20(1):279. doi: 10.1186/s13059-019-1897-7. PMID:31842968; PMCID: PMC6913009.
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Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs
Qu L, Yi ZY, Zhu ZY, Wang CH, Cao ZZ, Zhou Z, Yuan PF, Yu Y, Tian F, Liu ZH, Bao Y, Zhao YX and Wei WS. (2019). Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs. Nature Biotechnology 37, 1059-1069.
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Human Neonatal Fc Receptor Isthe Cellular Uncoating Receptor for Enterovirus B
Zhao X, Zhang G, Liu S, Chen X, Peng R, Dai L, Qu X, Li S, Song H, Gao Z,Yuan P, Liu Z, Li C, Shang Z, Li Y, Zhang M, Qi J, Wang H, Du N, Wu Y, Bi Y, GaoS, Shi Y, Yan J, Zhang Y, Xie Z, Wei W, Gao GF. Human Neonatal Fc Receptor Isthe Cellular Uncoating Receptor for Enterovirus B. Cell. 2019 May30;177(6):1553-1565.e16. doi: 10.1016/j.cell.2019.04.035. Epub 2019 May 16.PMID: 31104841; PMCID: PMC7111318.
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GuideRNAs with embedded barcodes boost CRISPR-pooled screens
Zhu S, Cao Z, Liu Z, He Y, Wang Y, Yuan P, Li W, Tian F, Bao Y, Wei W. GuideRNAs with embedded barcodes boost CRISPR-pooled screens. Genome Biol. 2019 Jan24;20(1):20. doi: 10.1186/s13059-019-1628-0. PMID: 30678704; PMCID: PMC6345036.
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Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites
Liu Y, Cao ZZ, Wang YN, Guo Y, Xu P, Yuan PF, Liu ZH, He Y and Wei WS. (2018). Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites. Nature Biotechnology 36, 1203-1210.
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Prepairing Cas9s for screening success
Zhou Z, Wei W. PrePAIRing Cas9s for screening success. Nat Biotechnol. 2018 Feb 6;36(2):147-148. doi: 10.1038/nbt.4075. PubMed PMID: 29406510.
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A surrogate reporter system for multiplexable evaluation of CRISPR/Cas9 in targeted mutagenesis
Zhang H, Zhou Y, Wang Y, Zhao Y, Qiu Y, Zhang X, Yue D, Zhou Z, Wei W. A surrogate reporter system for multiplexable evaluation of CRISPR/Cas9 in targeted mutagenesis. Sci Rep. 2018 Jan 18;8(1):1042. doi: 10.1038/s41598-018-19317-x. PubMed PMID: 29348585; PubMed Central PMCID: PMC5773543.
